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Issue 7, 2018
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Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

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Abstract

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.

Graphical abstract: Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

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Publication details

The article was received on 09 Jan 2018, accepted on 16 Jan 2018 and first published on 16 Jan 2018


Article type: Communication
DOI: 10.1039/C8OB00067K
Org. Biomol. Chem., 2018,16, 1079-1082

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    Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives

    J. Q. Huang, Z. Nairoukh and I. Marek, Org. Biomol. Chem., 2018, 16, 1079
    DOI: 10.1039/C8OB00067K

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