Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

Norihiro Sato; Shuntaro Takahashi; Hisae Tateishi-Karimata; Madoka E. Hazemi; Tomoko Chikuni; Kazumitsu Onizuka; Naoki Sugimoto; Fumi Nagatsugi

doi:10.1039/C7OB03179C

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Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA†

Norihiro Sato,^a Shuntaro Takahashi,^b Hisae Tateishi-Karimata,^b Madoka E. Hazemi,^a Tomoko Chikuni,^a Kazumitsu Onizuka,^a Naoki Sugimoto

^b and Fumi Nagatsugi

*^a

Author affiliations

* Corresponding authors

^a Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Japan
E-mail: nagatugi@tagen.tohoku.ac.jp
Tel: +81-22-217-5633

^b Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe 650-0047, Japan

Abstract

The G-quadruplex structure has been found in biologically significant regions of the genomic DNA, including the telomere and promoter regions, and is known to play an important role in a number of biological processes. In this paper, we report the development of alkylating probes for the G-quadruplex structure and evaluation of the properties of the modified G-quadruplex structure.

This article is part of the themed collection: Chemical Biology in OBC

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DOI: https://doi.org/10.1039/C7OB03179C
Article type: Communication
Submitted: 25 Dec 2017
Accepted: 30 Jan 2018
First published: 30 Jan 2018

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Org. Biomol. Chem., 2018,16, 1436-1441

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Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

N. Sato, S. Takahashi, H. Tateishi-Karimata, M. E. Hazemi, T. Chikuni, K. Onizuka, N. Sugimoto and F. Nagatsugi, Org. Biomol. Chem., 2018, 16, 1436 DOI: 10.1039/C7OB03179C

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Organic & Biomolecular Chemistry

Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA†

Abstract

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Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

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