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Issue 7, 2018
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Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones

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Abstract

An efficient, convenient short synthetic procedure for the synthesis of the intricate 5A5B6C-ring fusion topologies of tricyclic spiranoid β-hydroxybutyrolactones through lactonization of the key intermediate trans-α-hydroxyindenones with malonates is described. All the compounds synthesized exhibited environmentally benign characteristics, moderate fungicidal, nematocidal, and anti-TMV activities.

Graphical abstract: Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones

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Article information


Submitted
03 Nov 2017
Accepted
18 Jan 2018
First published
18 Jan 2018

Org. Biomol. Chem., 2018,16, 1163-1166
Article type
Paper

Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones

Y. J. Zhu, J. Q. Huo, Z. J. Fan, Q. F. Wu, X. Li, S. Zhou, L. X. Xiong, T. Kalinina and T. Glukhareva, Org. Biomol. Chem., 2018, 16, 1163
DOI: 10.1039/C7OB02701J

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