Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 3, 2018
Previous Article Next Article

Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions

Author affiliations

Abstract

An efficient, transition-metal free and direct C-arylation of 3-hydroxychromone moieties in the presence of a base, air as an oxidant and arylhydrazines as arylating agents to furnish highly biologically active flavonols or 3-hydroxyflavones has been developed. We have further extended our methodology for the C-arylation of the 5-hydroxy pyran-4-one moiety. The role of the free hydroxyl group towards C-arylation has been delineated.

Graphical abstract: Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions

Back to tab navigation

Supplementary files

Article information


Submitted
02 Aug 2017
Accepted
12 Dec 2017
First published
12 Dec 2017

Org. Biomol. Chem., 2018,16, 444-451
Article type
Paper

Hydroxyl directed C-arylation: synthesis of 3-hydroxyflavones and 2-phenyl-3-hydroxy pyran-4-ones under transition-metal free conditions

S. Paul and A. K. Bhattacharya, Org. Biomol. Chem., 2018, 16, 444
DOI: 10.1039/C7OB01929G

Social activity

Search articles by author

Spotlight

Advertisements