Issue 46, 2017

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Abstract

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space–time yield of 2 g L−1 d−1.

Graphical abstract: A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Supplementary files

Article information

Article type
Communication
Submitted
17 Oct 2017
Accepted
10 Nov 2017
First published
10 Nov 2017

Org. Biomol. Chem., 2017,15, 9790-9793

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

M. Tavanti, J. Mangas-Sanchez, S. L. Montgomery, M. P. Thompson and N. J. Turner, Org. Biomol. Chem., 2017, 15, 9790 DOI: 10.1039/C7OB02569F

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