Issue 45, 2017
From the journal:

Organic & Biomolecular Chemistry

Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters†

Amit Kumar Yadav,ab   Namit Dey,c   Sabyasachi Chattopadhyay,c   Munia Ganguli*bc  and  Moneesha Fernandes ORCID logo *ab  

* Corresponding authors

a Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr Homi Bhabha Road, Pune 411008, India
E-mail: m.dcosta@ncl.res.in

b Academy of Scientific and Innovative Research (AcSIR), CSIR-NCL Campus, Pune, India

c CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi 110020, India
E-mail: mganguli@igib.in

Abstract

Amide- and carbamate-linked dendrimeric oligomers are reported as molecular transporters. They effectively complex with pDNA and transport it into cells at an efficiency superior to Lipofectamine, when complexation is carried out by incubation overnight. The carbamate-linked K2C is superior to amide-linked K2A; their pDNA complexes have very low associated cytotoxicity.

Graphical abstract: Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C7OB02552A
Article type
Communication
Submitted
16 Oct 2017
Accepted
30 Oct 2017
First published
30 Oct 2017

Org. Biomol. Chem., 2017,15, 9579-9584

Permissions

Request permissions

Dendrimeric amide- and carbamate-linked lysine-based efficient molecular transporters

A. K. Yadav, N. Dey, S. Chattopadhyay, M. Ganguli and M. Fernandes, Org. Biomol. Chem., 2017, 15, 9579 DOI: 10.1039/C7OB02552A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements