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Issue 44, 2017
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Chemoselective N-arylation of aminobenzamides via copper catalysed Chan–Evans–Lam reactions

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Abstract

Chemoselective N-arylation of unprotected aminobenzamides was achieved via Cu-catalysed Chan–Evans–Lam cross-coupling with aryl boronic acids for the first time. Simple copper catalysts enable the selective arylation of amino groups in ortho/meta/para-aminobenzamides under open-flask conditions. The reactions were scalable and compatible with a wide range of functional groups.

Graphical abstract: Chemoselective N-arylation of aminobenzamides via copper catalysed Chan–Evans–Lam reactions

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Article information


Submitted
08 Oct 2017
Accepted
23 Oct 2017
First published
23 Oct 2017

Org. Biomol. Chem., 2017,15, 9288-9292
Article type
Communication

Chemoselective N-arylation of aminobenzamides via copper catalysed Chan–Evans–Lam reactions

S. Liu, W. Zu, J. Zhang and L. Xu, Org. Biomol. Chem., 2017, 15, 9288
DOI: 10.1039/C7OB02491F

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