Issue 38, 2017

Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

Abstract

A room-temperature and PTC-free copper-catalyzed N-arylation of aliphatic amines in neat water has been developed. Using a combination of CuI and 6,7-dihydroquinolin-8(5H)-one oxime as the catalyst and KOH as the base, a wide range of aliphatic amines are arylated with various aryl and heteroaryl halides to give the corresponding products in up to 95% yield.

Graphical abstract: Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

Supplementary files

Article information

Article type
Communication
Submitted
25 Aug 2017
Accepted
11 Sep 2017
First published
11 Sep 2017

Org. Biomol. Chem., 2017,15, 8009-8012

Room-temperature Cu-catalyzed N-arylation of aliphatic amines in neat water

D. Wang, Y. Zheng, M. Yang, F. Zhang, F. Mao, J. Yu and X. Xia, Org. Biomol. Chem., 2017, 15, 8009 DOI: 10.1039/C7OB02126G

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