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Issue 39, 2017
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Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

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Abstract

The methodology of direct C(sp2)–H functionalization has for the first time been applied as an efficient and advanced approach to carry out C–H/C–H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical method used does not require either any auxiliary group in the starting substrates, or catalysis by transition metals. As a result, a number of novel 1H-pyrrol-2-yl-2H-imidazoles, that are particularly of interest in the design of bioactive molecules, have been prepared under mild conditions and in good to excellent yields.

Graphical abstract: Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

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Article information


Submitted
11 Aug 2017
Accepted
12 Sep 2017
First published
13 Sep 2017

Org. Biomol. Chem., 2017,15, 8280-8284
Article type
Communication

Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles

M. Varaksin, T. Moseev, O. Chupakhin, V. Charushin and B. Trofimov, Org. Biomol. Chem., 2017, 15, 8280
DOI: 10.1039/C7OB01999H

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