Issue 33, 2017
From the journal:

Organic & Biomolecular Chemistry

Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation†

Yu Zhang,a   Xue-Ke Liu,a   Zheng-Guang Wu,*a   Yi Wang ORCID logo *a  and  Yi Panabc  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: yiwang@nju.edu.cn
Fax: +86-25-83309123
Tel: +86-25-89683153

b State of Key Laboratory of Coordination, Nanjing University, Nanjing, China

c Collaborative Innovation Center of Advanced Microstructures, Nanjing, China

Abstract

A solvent controlled regioselective metal-free synthesis of iodo-substituted N-heterocycles has been developed. This protocol undergoes a cascade iodination/cyclization/oxidation/aromatization pathway to afford multi-halogenated quinolines from readily available propargylamines under mild conditions.

Graphical abstract: Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation

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Article information

DOI
https://doi.org/10.1039/C7OB01637A
Article type
Communication
Submitted
05 Jul 2017
Accepted
31 Jul 2017
First published
31 Jul 2017

Org. Biomol. Chem., 2017,15, 6901-6904

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Solvent controlled radical cyclization of propargylamines for multi-iodinated quinoline formation

Y. Zhang, X. Liu, Z. Wu, Y. Wang and Y. Pan, Org. Biomol. Chem., 2017, 15, 6901 DOI: 10.1039/C7OB01637A

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