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Issue 26, 2017
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Ru-Catalyzed highly diastereoselective hydrogenation of N-tert-butylsulfinyl ketimines for the synthesis of aryl glycine derivatives

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Abstract

A ruthenium pincer catalyst has been shown to be highly efficient for the hydrogenation of a wide range of α-ketimino esters derived from α-keto esters and chiral 2-methylpropyl-2-sulfinamide, affording chiral aryl glycine derivatives with high yields and diasteroselectivities (20 examples, dr values up to 99 : 1).

Graphical abstract: Ru-Catalyzed highly diastereoselective hydrogenation of N-tert-butylsulfinyl ketimines for the synthesis of aryl glycine derivatives

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Article information


Submitted
31 May 2017
Accepted
15 Jun 2017
First published
15 Jun 2017

Org. Biomol. Chem., 2017,15, 5468-5471
Article type
Communication

Ru-Catalyzed highly diastereoselective hydrogenation of N-tert-butylsulfinyl ketimines for the synthesis of aryl glycine derivatives

Q. Wei, F. Zhang, X. Zhao, C. Wang, J. Xiao and W. Tang, Org. Biomol. Chem., 2017, 15, 5468
DOI: 10.1039/C7OB01329A

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