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Issue 26, 2017
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t-BuOK-mediated reductive addition of P(O)–H compounds to terminal alkynes forming β-arylphosphine oxides

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Abstract

A novel and efficient t-BuOK-mediated reductive addition of P(O)–H compounds to terminal alkynes was developed. A variety of β-arylphosphine oxides including the valuable β-heteroarylphosphine oxides were produced in moderate to high yields under mild reaction conditions. This reaction may proceed via a tandem process involving regio-selective double addition and subsequent transfer hydrogenation.

Graphical abstract: t-BuOK-mediated reductive addition of P(O)–H compounds to terminal alkynes forming β-arylphosphine oxides

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Article information


Submitted
05 May 2017
Accepted
12 Jun 2017
First published
13 Jun 2017

Org. Biomol. Chem., 2017,15, 5462-5467
Article type
Communication

t-BuOK-mediated reductive addition of P(O)–H compounds to terminal alkynes forming β-arylphosphine oxides

J. Zhang, J. Zhang, T. Chen and L. Han, Org. Biomol. Chem., 2017, 15, 5462
DOI: 10.1039/C7OB01104K

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