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Issue 22, 2017
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Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines

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Abstract

A simple and convenient method has been developed for the construction of sulfonamides via I2O5-mediated sulfonylation of amines with arylthiols. The present protocol provides an attractive approach to sulfonamides in moderate to good yields from readily accessible and easy to handle starting materials under mild and metal-free conditions.

Graphical abstract: Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines

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Article information


Submitted
17 Mar 2017
Accepted
10 May 2017
First published
12 May 2017

Org. Biomol. Chem., 2017,15, 4789-4793
Article type
Communication

Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines

M. Zhu, W. Wei, D. Yang, H. Cui, L. Wang, G. Meng and H. Wang, Org. Biomol. Chem., 2017, 15, 4789
DOI: 10.1039/C7OB00668C

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