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Issue 17, 2017
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Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes

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Abstract

The structural basis for the intracellular delivery of OSW-1 is investigated using fluorescent derivatives of OSW-1 and its closely related congeners. Despite the large differences in activity, all the fluorescent probes are found to translocate across the plasma membrane to the ER and Golgi apparatus. This observation suggests that the glycosylated cholestane moiety plays an important role in the cell internalization and intracellular localization property of OSW-1.

Graphical abstract: Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes

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Article information


Submitted
27 Feb 2017
Accepted
14 Mar 2017
First published
27 Mar 2017

Org. Biomol. Chem., 2017,15, 3568-3570
Article type
Communication

Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes

M. Hiraizumi, R. Komatsu, T. Shibata, Y. Ohta and K. Sakurai, Org. Biomol. Chem., 2017, 15, 3568
DOI: 10.1039/C7OB00486A

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