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Issue 11, 2017
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Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles

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Abstract

The synthesis of monofluoroalkenes bearing a malonate or its derivatives at the β position is presented. The reaction can be performed with various 3,3-difluoropropenes. A preliminary result for an enantioselective variant is also reported. Further synthetic transformations of a monofluoroalkene were also accomplished.

Graphical abstract: Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles

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Article information


Submitted
15 Feb 2017
Accepted
21 Feb 2017
First published
28 Feb 2017

Org. Biomol. Chem., 2017,15, 2376-2384
Article type
Paper

Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles

M. Drouin, S. Tremblay and J. Paquin, Org. Biomol. Chem., 2017, 15, 2376
DOI: 10.1039/C7OB00376E

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