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Issue 11, 2017
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Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

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Abstract

A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds using a novel palladium-catalyzed tandem cyclization reaction is explored. During the reaction process, C–O, C–C and C–O bonds are sequentially formed in one pot via decarboxylative allenylpalladium formation, nucleophilic attack, arylpalladium addition and intramolecular nucleophilic attack.

Graphical abstract: Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

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Article information


Submitted
26 Dec 2016
Accepted
24 Feb 2017
First published
02 Mar 2017

Org. Biomol. Chem., 2017,15, 2403-2410
Article type
Paper

Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

L. Wang, X. Li, H. Tao, X. Zhou, X. Lu, W. Du, T. Jiang, Z. Xin and J. Liang, Org. Biomol. Chem., 2017, 15, 2403
DOI: 10.1039/C6OB02802K

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