Issue 5, 2017
From the journal:

Organic & Biomolecular Chemistry

Expedient and modular access to 2-azabicyclic architectures by iron-catalyzed dehydrative coupling of alcohol-bearing allylic lactams†‡

Katie Hovenkotter,a   Hannah Braunstein,a   Spencer Langevina  and  Timothy K. Beng ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Central Washington University, Ellensburg, WA 98926, USA
E-mail: TimothyB@cwu.edu

Abstract

A high-yielding, cost-effective, modular and environmentally benign approach to [5,5]- or [6,5]-2-azabicyclic architectures bearing vicinal stereocenters, by Fe-catalyzed intramolecular dehydrative coupling of readily affordable alcohol-bearing allylic lactams is presented.

Graphical abstract: Expedient and modular access to 2-azabicyclic architectures by iron-catalyzed dehydrative coupling of alcohol-bearing allylic lactams

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Article information

DOI
https://doi.org/10.1039/C6OB02652D
Article type
Paper
Submitted
05 Dec 2016
Accepted
05 Jan 2017
First published
16 Jan 2017

Org. Biomol. Chem., 2017,15, 1217-1221

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Expedient and modular access to 2-azabicyclic architectures by iron-catalyzed dehydrative coupling of alcohol-bearing allylic lactams

K. Hovenkotter, H. Braunstein, S. Langevin and T. K. Beng, Org. Biomol. Chem., 2017, 15, 1217 DOI: 10.1039/C6OB02652D

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