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Issue 1, 2017
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1,6-Conjugate addition of zinc alkyls to para-quinone methides in a continuous-flow microreactor

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Abstract

An efficient method for the synthesis of alkyl diarylmethanes through the 1,6-conjugate addition of dialkylzinc reagents to para-quinone methides (p-QMs) has been developed under continuous flow conditions using a microreactor. This protocol allows to access unsymmetrical alkyl diarylmethanes in moderate to excellent yields using a wide range of p-QMs and dialkylzinc reagents. Interestingly, this transformation worked well without the requirement of a catalyst.

Graphical abstract: 1,6-Conjugate addition of zinc alkyls to para-quinone methides in a continuous-flow microreactor

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Supplementary files

Article information


Submitted
18 Oct 2016
Accepted
01 Nov 2016
First published
01 Nov 2016

Org. Biomol. Chem., 2017,15, 56-60
Article type
Communication

1,6-Conjugate addition of zinc alkyls to para-quinone methides in a continuous-flow microreactor

A. S. Jadhav and R. V. Anand, Org. Biomol. Chem., 2017, 15, 56
DOI: 10.1039/C6OB02277D

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