Issue 33, 2016

Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

Abstract

3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with two neopentylene-fused analogues of the synthetic anti-inflammatory drug, ibuprofen.

Graphical abstract: Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2016
Accepted
01 Aug 2016
First published
01 Aug 2016

Org. Biomol. Chem., 2016,14, 7855-7858

Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

R. R. Ramsubhag, C. L. Massaro, C. M. Dadich, A. J. Janeczek, T. T. Hoang, E. A. Mazzio, S. Eyunni, K. F. A. Soliman and G. B. Dudley, Org. Biomol. Chem., 2016, 14, 7855 DOI: 10.1039/C6OB01351A

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