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Issue 34, 2016
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A bactericidal calix[4]arene-based nanoconstruct with amplified NO photorelease

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Abstract

A hydrophobic N-dodecyl-3-(trifluoromethyl)-4-nitrobenzenamine has been synthesized as a suitable NO photodonor and encapsulated in a nanocontainer based on a polycationic calix[4]arene derivative, leading to a supramolecular micellar-like nanoassembly ca. 45 nm in diameter. Visible light excitation of this nanoconstruct triggers NO generation with an efficiency remarkably higher than that observed for the free NO photoreleaser. This amplified NO release results in considerable antibacterial activity against Staphylococcus aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 9027) as representative Gram positive and Gram negative bacteria, respectively.

Graphical abstract: A bactericidal calix[4]arene-based nanoconstruct with amplified NO photorelease

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Supplementary files

Article information


Submitted
16 Jun 2016
Accepted
01 Jul 2016
First published
07 Jul 2016

Org. Biomol. Chem., 2016,14, 8047-8052
Article type
Paper

A bactericidal calix[4]arene-based nanoconstruct with amplified NO photorelease

I. Di Bari, R. Picciotto, G. Granata, A. R. Blanco, G. M. L. Consoli and S. Sortino, Org. Biomol. Chem., 2016, 14, 8047
DOI: 10.1039/C6OB01305H

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