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Issue 36, 2016
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Copper-catalysed oxidative amination of quinoxalin-2(1H)-ones with aliphatic amines

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Abstract

A novel, efficient and practical method for copper-catalysed oxidative C-3 amination of quinoxalin-2(1H)-ones with primary or secondary amines as the nitrogen sources has been developed. A wide variety of 3-aminoquinoxalin-2(1H)-ones were prepared in up to 98% yield with good functional group tolerance for 24 examples. This synthetic strategy features atom economy, concise steps, easy operation, and mild reaction conditions.

Graphical abstract: Copper-catalysed oxidative amination of quinoxalin-2(1H)-ones with aliphatic amines

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Article information


Submitted
14 Jun 2016
Accepted
13 Jul 2016
First published
13 Jul 2016

Org. Biomol. Chem., 2016,14, 8428-8432
Article type
Communication

Copper-catalysed oxidative amination of quinoxalin-2(1H)-ones with aliphatic amines

Y. Li, M. Gao, L. Wang and X. Cui, Org. Biomol. Chem., 2016, 14, 8428
DOI: 10.1039/C6OB01283C

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