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Issue 32, 2016
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Synthesis of α-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction

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Abstract

α-Sulfenyl ketones are potential precursors which find a variety of applications in organic synthesis. Their typical synthesis requires pre-functionalized starting materials and two to three step synthetic sequences. In addition, the selective pre-functionalization of unsymmetrical ketones is a challenge, which limits the synthesis of the desired sulfenylated ketones. To overcome these disadvantages, a metal-free, convenient one-step strategy for synthesizing α-sulfenyl ketones at ambient temperature via a cross-dehydrogenative coupling (CDC) strategy has been developed with a broad substrate scope. Therefore, this CDC strategy for C–S bond formation is attractive and may find wide applications in organic synthesis.

Graphical abstract: Synthesis of α-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction

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Supplementary files

Article information


Submitted
07 Jun 2016
Accepted
15 Jul 2016
First published
15 Jul 2016

Org. Biomol. Chem., 2016,14, 7665-7670
Article type
Paper

Synthesis of α-sulfenyl monoketones via a metal-free oxidative cross dehydrogenative coupling (CDC) reaction

B. V. Varun, K. Gadde and K. R. Prabhu, Org. Biomol. Chem., 2016, 14, 7665
DOI: 10.1039/C6OB01243D

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