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Issue 29, 2016
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Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines

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Abstract

A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines has been successfully developed, providing direct and facile access to chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethylthio group with up to 99% enantioselectivity.

Graphical abstract: Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines

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Publication details

The article was received on 31 May 2016, accepted on 17 Jun 2016 and first published on 20 Jun 2016


Article type: Communication
DOI: 10.1039/C6OB01176D
Org. Biomol. Chem., 2016,14, 6937-6941

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    Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines

    J. Zhou, Q. Zhang, W. Zhao and G. Jiang, Org. Biomol. Chem., 2016, 14, 6937
    DOI: 10.1039/C6OB01176D

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