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Issue 28, 2016
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Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

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Abstract

An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.

Graphical abstract: Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

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Publication details

The article was received on 30 Apr 2016, accepted on 08 Jun 2016 and first published on 08 Jun 2016


Article type: Paper
DOI: 10.1039/C6OB00945J
Org. Biomol. Chem., 2016,14, 6786-6794

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    Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides

    C. R. Dantas, J. J. R. de Freitas, Q. P. S. Barbosa, G. C. G. Militão, T. D. S. Silva, T. G. da Silva, A. A. S. Paulino, J. C. R. Freitas, R. A. Oliveira and P. H. Menezes, Org. Biomol. Chem., 2016, 14, 6786
    DOI: 10.1039/C6OB00945J

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