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Issue 27, 2016
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Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review

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Abstract

The first enantioselective synthesis was the selective addition of cyanide to benzaldehyde catalysed by a hydroxynitrile lyase (HNL). Since then these enzymes have been developed into a reliable tool in organic synthesis. HNLs to prepare either the (R)- or the (S)-enantiomer of the desired cyanohydrin are available and a wide variety of reaction conditions can be applied. As a result of this, numerous applications of these enzymes in organic synthesis have been described. Here the examples of the last decade are summarised, the enzyme catalysed step is discussed and the follow-up chemistry is shown. This proves HNLs to be part of main stream organic synthesis. Additionally the newest approaches via immobilisation and reaction engineering are introduced.

Graphical abstract: Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review

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Article information


Submitted
29 Apr 2016
Accepted
31 May 2016
First published
01 Jun 2016

This article is Open Access

Org. Biomol. Chem., 2016,14, 6375-6389
Article type
Review Article

Enantioselective synthesis of cyanohydrins catalysed by hydroxynitrile lyases – a review

P. Bracco, H. Busch, J. von Langermann and U. Hanefeld, Org. Biomol. Chem., 2016, 14, 6375
DOI: 10.1039/C6OB00934D

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