Issue 23, 2016
From the journal:

Organic & Biomolecular Chemistry

Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1–C15 fragment†

Joana Zambrana,a   Pedro Romea*a  and  Fèlix Urpí*a  

* Corresponding authors

a Secció de Química Orgànica, Departament de Química Inorgànica i Orgànica, and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain
E-mail: pedro.romea@ub.edu, felix.urpi@ub.edu

Abstract

The preparation of an advanced intermediate on route towards the synthesis of tedanolide C is reported here. It is based on the coupling of two fragments of similar size and complexity, which in turn are prepared by highly stereoselective substrate-controlled titanium-mediated aldol reactions from chiral ketones.

Graphical abstract: Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1–C15 fragment

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Article information

DOI
https://doi.org/10.1039/C6OB00896H
Article type
Communication
Submitted
26 Apr 2016
Accepted
17 May 2016
First published
17 May 2016

Org. Biomol. Chem., 2016,14, 5219-5223

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Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1–C15 fragment

J. Zambrana, P. Romea and F. Urpí, Org. Biomol. Chem., 2016, 14, 5219 DOI: 10.1039/C6OB00896H

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