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Issue 32, 2016
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Chemically synthesized glycoconjugates on proteins: effects of multivalency and glycoform in vivo

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Abstract

The biodistributions and in vivo kinetics of chemically prepared glycoconjugates on proteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intravenous injections, have been analyzed using conventional dissection studies as well as non-invasive methods such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and fluorescence imaging. The results suggest that glycan-dependent protein distribution kinetics may be useful for pharmacological and diagnostic applications.

Graphical abstract: Chemically synthesized glycoconjugates on proteins: effects of multivalency and glycoform in vivo

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Publication details

The article was received on 01 Apr 2016, accepted on 02 Jun 2016 and first published on 02 Jun 2016


Article type: Review Article
DOI: 10.1039/C6OB00788K
Citation: Org. Biomol. Chem., 2016,14, 7610-7621

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    Chemically synthesized glycoconjugates on proteins: effects of multivalency and glycoform in vivo

    K. Tanaka, Org. Biomol. Chem., 2016, 14, 7610
    DOI: 10.1039/C6OB00788K

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