Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.
D. J. Leng, C. M. Black and G. Pattison, Org. Biomol. Chem., 2016, 14, 1531 DOI: 10.1039/C5OB02468D
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