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Issue 1, 2016
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Copper-catalyzed direct C–H fluoroalkenylation of heteroarenes

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Abstract

Copper-catalyzed direct C–H fluoroalkenylation of heterocycles using various gem-bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of biomolecules and therapeutic agents for the treatment of Duchenne muscular dystrophy as application is reported.

Graphical abstract: Copper-catalyzed direct C–H fluoroalkenylation of heteroarenes

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Supplementary files

Article information


Submitted
26 Oct 2015
Accepted
13 Nov 2015
First published
25 Nov 2015

Org. Biomol. Chem., 2016,14, 353-357
Article type
Paper
Author version available

Copper-catalyzed direct C–H fluoroalkenylation of heteroarenes

K. Rousée, C. Schneider, J. Bouillon, V. Levacher, C. Hoarau, S. Couve-Bonnaire and X. Pannecoucke, Org. Biomol. Chem., 2016, 14, 353
DOI: 10.1039/C5OB02213D

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