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Issue 48, 2015
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Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine

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Abstract

Exploration of novel chemical space, a modern trend in medicinal chemistry, is heavily reliant on synthetic access to new and interesting building blocks. In this direction, the following work describes an expedient synthesis of one such moiety, 3-fluorobicyclo[1.1.1]pentan-1-amine, by employing radical fluorination.

Graphical abstract: Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine

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Article information


Submitted
06 Oct 2015
Accepted
29 Oct 2015
First published
02 Nov 2015

Org. Biomol. Chem., 2015,13, 11597-11601
Article type
Communication
Author version available

Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine

Y. L. Goh and V. A. Adsool, Org. Biomol. Chem., 2015, 13, 11597
DOI: 10.1039/C5OB02066B

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