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Issue 39, 2015
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Copper-catalyzed cyanation of aryl iodides with α-cyanoacetates via C–CN bond activation

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Abstract

A Cu(I)-catalyzed cyanation reaction of aryl iodides with α-cyanoacetates is reported herein, which uses α-cyanoacetates as the nontoxic and easy-handling CN source through copper-mediated C–CN bond cleavage. This reaction enables access to aryl nitriles with an array of functional groups on the aromatic ring in good to excellent yields.

Graphical abstract: Copper-catalyzed cyanation of aryl iodides with α-cyanoacetates via C–CN bond activation

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Supplementary files

Article information


Submitted
09 Aug 2015
Accepted
13 Aug 2015
First published
13 Aug 2015

Org. Biomol. Chem., 2015,13, 9963-9968
Article type
Paper

Copper-catalyzed cyanation of aryl iodides with α-cyanoacetates via C–CN bond activation

S. Zhang and L. Huang, Org. Biomol. Chem., 2015, 13, 9963
DOI: 10.1039/C5OB01675D

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