Issue 39, 2015
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed N-methylation/ethylation of sulfoximines†

Fan Teng,a   Jiang Chenga  and  Jin-Tao Yu*a  

* Corresponding authors

a School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China
E-mail: yujintao@cczu.edu.cn

Abstract

A protocol for the copper-catalyzed N-methylation of sulfoximines with di-tert-butyl peroxide (DTBP) was developed. This protocol has good functional group tolerance leading to N-methylated sulfoximines in moderate to good yields. Besides, N-ethylation of sulfoximines was achieved in the presence of bis(1,1-dimethylpropyl)peroxide as the ethylating agent under a standard procedure.

Graphical abstract: Copper-catalyzed N-methylation/ethylation of sulfoximines

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Article information

DOI
https://doi.org/10.1039/C5OB01558H
Article type
Communication
Submitted
27 Jul 2015
Accepted
24 Aug 2015
First published
25 Aug 2015

Org. Biomol. Chem., 2015,13, 9934-9937

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Copper-catalyzed N-methylation/ethylation of sulfoximines

F. Teng, J. Cheng and J. Yu, Org. Biomol. Chem., 2015, 13, 9934 DOI: 10.1039/C5OB01558H

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