Conformational promiscuity in triazolamers derived from quaternary amino acids mimics peptide behaviour

Abstract

1,4-Substituted triazole oligomers made from quaternary amino acid derivatives present a conformational behaviour with similarities to that of natural peptides. Twisted strand and zig-zag type conformations have both been obtained in the crystal state. In a solution signs of weakly ordered structures have been detected depending on the substituents and the solvents used.