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Issue 37, 2015
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Stable analogues of nojirimycin – synthesis and biological evaluation of nojiristegine and manno-nojiristegine

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Abstract

Two novel iminosugars called nojiristegines, being structural hybrids between nor-tropane alkaloid calystegine and nojirimycins, have been synthesised and found to be stable molecules despite the presence of a hemiaminal functionality. The synthesised iminosugars were evaluated against a panel of glycosidases and the best inhibition (IC50), found against α-glucosidases, was in the micromolar region. The compounds were also evaluated as potential antibiotics but no useful level of activity was observed.

Graphical abstract: Stable analogues of nojirimycin – synthesis and biological evaluation of nojiristegine and manno-nojiristegine

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Publication details

The article was received on 23 Jun 2015, accepted on 14 Jul 2015 and first published on 14 Jul 2015


Article type: Paper
DOI: 10.1039/C5OB01281C
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Org. Biomol. Chem., 2015,13, 9637-9658

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    Stable analogues of nojirimycin – synthesis and biological evaluation of nojiristegine and manno-nojiristegine

    A. H. Viuff, L. M. Besenbacher, A. Kamori, M. T. Jensen, M. Kilian, A. Kato and H. H. Jensen, Org. Biomol. Chem., 2015, 13, 9637
    DOI: 10.1039/C5OB01281C

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