Jump to main content
Jump to site search

Issue 26, 2015
Previous Article Next Article

Copper-catalysed ring-opening trifluoromethylation of cyclopropanols

Author affiliations

Abstract

A copper-catalysed ring-opening trifluoromethylation reaction of cyclopropanols has been developed. Various β-trifluoromethyl ketones are obtained in good to excellent yields under mild reaction conditions. The present method also exhibits good functional-group compatibility. The mechanism of this new ring-opening trifluoromethylation reaction was investigated by radical trapping reactions.

Graphical abstract: Copper-catalysed ring-opening trifluoromethylation of cyclopropanols

Back to tab navigation

Supplementary files

Article information


Submitted
22 Apr 2015
Accepted
29 May 2015
First published
02 Jun 2015

Org. Biomol. Chem., 2015,13, 7159-7163
Article type
Communication

Copper-catalysed ring-opening trifluoromethylation of cyclopropanols

X. He, Y. Shu, J. Dai, W. Zhang, Y. Feng and H. Xu, Org. Biomol. Chem., 2015, 13, 7159
DOI: 10.1039/C5OB00808E

Social activity

Search articles by author

Spotlight

Advertisements