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Issue 28, 2015
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Cyanine polyene reactivity: scope and biomedical applications

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Cyanines are indispensable fluorophores that form the chemical basis of many fluorescence-based applications. A feature that distinguishes cyanines from other common fluorophores is an exposed polyene linker that is both crucial to absorption and emission and subject to covalent reactions that dramatically alter these optical properties. Over the past decade, reactions involving the cyanine polyene have been used as foundational elements for a range of biomedical techniques. These include the optical sensing of biological analytes, super-resolution imaging, and near-IR light-initiated uncaging. This review surveys the chemical reactivity of the cyanine polyene and the biomedical methods enabled by these reactions. The overarching goal is to highlight the multifaceted nature of cyanine chemistry and biology, as well as to point out the key role of reactivity-based insights in this promising area.

Graphical abstract: Cyanine polyene reactivity: scope and biomedical applications

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Publication details

The article was received on 20 Apr 2015, accepted on 28 May 2015 and first published on 05 Jun 2015

Article type: Review Article
DOI: 10.1039/C5OB00788G
Org. Biomol. Chem., 2015,13, 7584-7598

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    Cyanine polyene reactivity: scope and biomedical applications

    A. P. Gorka, R. R. Nani and M. J. Schnermann, Org. Biomol. Chem., 2015, 13, 7584
    DOI: 10.1039/C5OB00788G

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