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Issue 25, 2015

Recent developments and applications of the Cadiot–Chodkiewicz reaction

Author affiliations

Abstract

The classical heterocoupling of a 1-haloalkyne with a terminal alkyne catalyzed by copper salts in the presence of a base for the synthesis of unsymmetrical diynes is termed the Cadiot–Chodkiewicz coupling reaction. The diynes are of great importance due to their biological, optical and electronic properties. A number of modifications have been developed recently to improve the efficiency of Cadiot–Chodkiewicz coupling reactions in terms of selectivity and yield. This is the first review on the Cadiot–Chodkiewicz cross-coupling reaction which highlights the modern approaches and protocols developed for the synthesis and applications of unsymmetrical 1,3-diynes.

Graphical abstract: Recent developments and applications of the Cadiot–Chodkiewicz reaction

Article information


Submitted
08 Apr 2015
Accepted
08 May 2015
First published
08 May 2015

Org. Biomol. Chem., 2015,13, 6891-6905
Article type
Review Article
Author version available

Recent developments and applications of the Cadiot–Chodkiewicz reaction

K. S. Sindhu, A. P. Thankachan, P. S. Sajitha and G. Anilkumar, Org. Biomol. Chem., 2015, 13, 6891 DOI: 10.1039/C5OB00697J

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