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Issue 15, 2015
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Ti(iv)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones

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Abstract

A tetrahydrofuro[3,2-d]oxazole scaffold was synthesized efficiently and stereoselectively. The tandem ionic hydrogenation, ketalization, and intramolecular cyclization of arene-1,4-diones with a combination of TiCl4/Et3SiH give facile access to tetrahydrofuro[3,2-d]oxazole derivatives in good yields at room temperature.

Graphical abstract: Ti(iv)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones

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Article information


Submitted
29 Jan 2015
Accepted
09 Mar 2015
First published
09 Mar 2015

Org. Biomol. Chem., 2015,13, 4418-4421
Article type
Communication

Ti(IV)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones

G. Li, L. Li, H. Huang and D. Yin, Org. Biomol. Chem., 2015, 13, 4418
DOI: 10.1039/C5OB00174A

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