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Issue 14, 2015
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One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles

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Abstract

This paper described a decarboxylative deaminative dual-coupling reaction of amino acids with indoles to afford BIM scaffolds and its further application to the one-pot total synthesis of natural products. This method featured a stimulating example of activating amino acids in one pot as multi-carbon building blocks for transformation into final targets which are equipped with amino acid side chain backbones.

Graphical abstract: One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles

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Supplementary files

Article information


Submitted
07 Jan 2015
Accepted
25 Feb 2015
First published
25 Feb 2015

Org. Biomol. Chem., 2015,13, 4240-4247
Article type
Paper

One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles

J. Xiang, J. Wang, M. Wang, X. Meng and A. Wu, Org. Biomol. Chem., 2015, 13, 4240 DOI: 10.1039/C5OB00025D

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