Jump to main content
Jump to site search

Issue 8, 2015
Previous Article Next Article

Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N–H) α-ketoamides

Author affiliations

Abstract

A highly efficient molecular iodine catalyzed oxidative amidation of aryl methyl ketones with formamidine hydrochloride has been developed. This reaction represents a novel strategy for the synthesis of free (N–H) α-ketoamides. Based on the experimental results, a self-sequenced iodination/Kornblum oxidation/amidation/oxidation/decarbonylation mechanism was proposed.

Graphical abstract: Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N–H) α-ketoamides

Back to tab navigation

Supplementary files

Article information


Submitted
12 Dec 2014
Accepted
04 Jan 2015
First published
05 Jan 2015

Org. Biomol. Chem., 2015,13, 2239-2242
Article type
Communication
Author version available

Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N–H) α-ketoamides

S. Liu, Q. Gao, X. Wu, J. Zhang, K. Ding and A. Wu, Org. Biomol. Chem., 2015, 13, 2239
DOI: 10.1039/C4OB02591A

Social activity

Search articles by author

Spotlight

Advertisements