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Issue 9, 2015
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Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

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Abstract

We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients.

Graphical abstract: Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

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Publication details

The article was received on 04 Dec 2014, accepted on 13 Jan 2015 and first published on 14 Jan 2015


Article type: Communication
DOI: 10.1039/C4OB02538E
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Org. Biomol. Chem., 2015,13, 2570-2573
  • Open access: Creative Commons BY-NC license
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    Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

    F. Doro, C. Colombo, C. Alberti, D. Arosio, L. Belvisi, C. Casagrande, R. Fanelli, L. Manzoni, E. Parisini, U. Piarulli, E. Luison, M. Figini, A. Tomassetti and M. Civera, Org. Biomol. Chem., 2015, 13, 2570
    DOI: 10.1039/C4OB02538E

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