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Issue 7, 2015
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Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

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Abstract

We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.

Graphical abstract: Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

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Supplementary files

Article information


Submitted
03 Dec 2014
Accepted
04 Dec 2014
First published
18 Dec 2014

Org. Biomol. Chem., 2015,13, 2022-2025
Article type
Paper
Author version available

Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

K. Usui, A. Okada, K. Kobayashi and N. Sugimoto, Org. Biomol. Chem., 2015, 13, 2022 DOI: 10.1039/C4OB02535K

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