Issue 9, 2015

Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media

Abstract

Decarboxylative alkylation or acylation reactions of simple pyrimidines have been developed in aqueous media. Using aliphatic carboxylic acids or 2-oxocarboxylic acids and pyrimidines as substrates and silver as the catalyst, the 4-substituted alkyl or acyl pyrimidines were isolated in moderate to good yields.

Graphical abstract: Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media

Article information

Article type
Paper
Submitted
02 Dec 2014
Accepted
06 Jan 2015
First published
06 Jan 2015

Org. Biomol. Chem., 2015,13, 2750-2755

Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media

W. Mai, B. Sun, L. You, L. Yang, P. Mao, J. Yuan, Y. Xiao and L. Qu, Org. Biomol. Chem., 2015, 13, 2750 DOI: 10.1039/C4OB02524E

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