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Issue 9, 2015
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Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy

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Abstract

A novel anticancer prodrug compound 1, which was designed to be triggered by thiols and release the chemotherapeutic agent mechlorethamine, was successfully prepared and evaluated for the first time. The activation of compound 1 was determined by NMR analysis and denaturing alkaline agarose gel electrophoresis. A fluorescence image and comet assay indicated that the inducible reactivity of 1 could be accomplished in cell media. The anticancer activities are also discussed.

Graphical abstract: Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy

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Article information


Submitted
24 Nov 2014
Accepted
02 Jan 2015
First published
02 Jan 2015

Org. Biomol. Chem., 2015,13, 2634-2639
Article type
Paper

Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy

Y. Xu, J. Chen, Y. Li, S. Peng, X. Gu, M. Sun, K. Gao and J. Fang, Org. Biomol. Chem., 2015, 13, 2634
DOI: 10.1039/C4OB02462A

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