Direct oxidative coupling of thiols and benzylic ethers via C(sp3)–H activation and C–O cleavage to lead thioesters

J. Feng; M.-F. Lv; G.-P. Lu; C. Cai

doi:10.1039/C4OB02250E

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Direct oxidative coupling of thiols and benzylic ethers via C(sp³)–H activation and C–O cleavage to lead thioesters†

J. Feng,^a M.-F. Lv,^a G.-P. Lu^a and C. Cai*^a

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* Corresponding authors

^a Chemical Engineering College, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing 210094, P. R. China
E-mail: c.cai@ njust.edu.cn
Fax: +86-25-84315030

Abstract

An unprecedented C–S formation method via direct oxidative C(sp³)–H bond functionalization and C–O cleavage of benzylic ethers was developed. Various thioesters including thioester structure containing drug intermediates could be achieved by this convenient, metal and base free method in satisfactory yields.

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Article information

DOI: https://doi.org/10.1039/C4OB02250E
Article type: Communication
Submitted: 22 Oct 2014
Accepted: 13 Nov 2014
First published: 14 Nov 2014

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Org. Biomol. Chem., 2015,13, 677-681

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Direct oxidative coupling of thiols and benzylic ethers via C(sp³)–H activation and C–O cleavage to lead thioesters

J. Feng, M.-F. Lv, G.-P. Lu and C. Cai, Org. Biomol. Chem., 2015, 13, 677 DOI: 10.1039/C4OB02250E

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Organic & Biomolecular Chemistry