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Issue 1, 2015
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An enantioselective total synthesis of Sch-725674

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Abstract

An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.

Graphical abstract: An enantioselective total synthesis of Sch-725674

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Publication details

The article was received on 07 Oct 2014, accepted on 29 Oct 2014 and first published on 30 Oct 2014


Article type: Paper
DOI: 10.1039/C4OB02136C
Org. Biomol. Chem., 2015,13, 234-240

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    An enantioselective total synthesis of Sch-725674

    K. Ramakrishna and K. P. Kaliappan, Org. Biomol. Chem., 2015, 13, 234
    DOI: 10.1039/C4OB02136C

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