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Issue 6, 2015
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Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

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Abstract

A chemoenzymatic two-step cascade process, with both steps having incompatible reaction conditions, was successfully performed in continuous flow. The chemoenzymatic aqueous formation of cyanohydrins was integrated with a subsequent organic phase protection step in a single flow process utilising a membrane-based phase separation module. The wider applicability of our setup was demonstrated with the synthesis of nine protected cyanohydrin derivatives, all obtained in good yields and high to excellent enantioselectivity.

Graphical abstract: Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

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Supplementary files

Article information


Submitted
05 Oct 2014
Accepted
08 Dec 2014
First published
08 Dec 2014

This article is Open Access

Org. Biomol. Chem., 2015,13, 1634-1638
Article type
Communication
Author version available

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

M. M. E. Delville, K. Koch, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2015, 13, 1634 DOI: 10.1039/C4OB02128B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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