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Issue 1, 2015
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Multivalent helix mimetics for PPI-inhibition

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Abstract

The exploitation of multivalent ligands for the inhibition of protein–protein interactions has not yet been explored as a supramolecular design strategy. This is despite the fact that protein–protein interactions typically occur within the context of multi-protein complexes and frequently exploit avidity effects or co-operative binding interactions to achieve high affinity interactions. In this paper we describe preliminary studies on the use of a multivalent N-alkylated aromatic oligoamide helix mimetic for inhibition of p53/hDM2 and establish that protein dimerisation is promoted, rather than enhanced binding resulting from a higher effective concentration of the ligand.

Graphical abstract: Multivalent helix mimetics for PPI-inhibition

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Supplementary files

Article information


Submitted
28 Sep 2014
Accepted
05 Nov 2014
First published
05 Nov 2014

This article is Open Access

Org. Biomol. Chem., 2015,13, 258-264
Article type
Paper
Author version available

Multivalent helix mimetics for PPI-inhibition

A. Barnard, J. A. Miles, G. M. Burslem, A. M. Barker and A. J. Wilson, Org. Biomol. Chem., 2015, 13, 258
DOI: 10.1039/C4OB02066A

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