Jump to main content
Jump to site search

Issue 2, 2015
Previous Article Next Article

Late-stage diversification of biologically active pyridazinones via a direct C–H functionalization strategy

Author affiliations

Abstract

Divergent C–H functionalization reactions (arylation, carboxylation, olefination, thiolation, acetoxylation, halogenation, naphthylation) using a pyridazinone moiety as an internal directing group were successfully established. This approach offers a late-stage, ortho-selective diversification of a biologically active pyridazinone scaffold. Seven series of novel pyridazinone analogues were synthesized conveniently as the synthetic precursors of potential sortase A (SrtA) inhibitors.

Graphical abstract: Late-stage diversification of biologically active pyridazinones via a direct C–H functionalization strategy

Back to tab navigation

Supplementary files

Article information


Submitted
28 Sep 2014
Accepted
22 Oct 2014
First published
22 Oct 2014

Org. Biomol. Chem., 2015,13, 539-548
Article type
Paper
Author version available

Late-stage diversification of biologically active pyridazinones via a direct C–H functionalization strategy

W. Li, Z. Fan, K. Geng, Y. Xu and A. Zhang, Org. Biomol. Chem., 2015, 13, 539
DOI: 10.1039/C4OB02061H

Social activity

Search articles by author

Spotlight

Advertisements