Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2015
Previous Article Next Article

Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

Author affiliations

Abstract

To date, DMF has been considered as the only solvent suitable for peptide synthesis. Here we demonstrate the capacity of THF and ACN, which are friendlier solvents than DMF, to yield the product in higher purity than DMF. Using various peptide models, both THF and ACN reduced racemization in solution-phase and solid-phase synthesis when compared with DMF. Moreover, the use of ACN and THF in the solid-phase peptide synthesis of hindered peptides, such as Aib-enkephalin pentapeptide and Aib-ACP decapeptide, in combination with a complete polyethylene glycol resin (ChemMatrix), gave a better coupling efficiency than DMF.

Graphical abstract: Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Sep 2014, accepted on 11 Dec 2014 and first published on 16 Dec 2014


Article type: Paper
DOI: 10.1039/C4OB02046D
Author version
available:
Download author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 2393-2398

  •   Request permissions

    Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

    Y. E. Jad, G. A. Acosta, S. N. Khattab, B. G. de la Torre, T. Govender, H. G. Kruger, A. El-Faham and F. Albericio, Org. Biomol. Chem., 2015, 13, 2393
    DOI: 10.1039/C4OB02046D

Search articles by author

Spotlight

Advertisements